Detalhe da pesquisa
1.
PAC1 receptor mRNA and protein distribution in rat and human trigeminal and sphenopalatine ganglia, spinal trigeminal nucleus and in dura mater.
Cephalalgia
; 39(7): 827-840, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30582714
2.
Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking.
J Headache Pain
; 20(1): 44, 2019 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31039731
3.
AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer.
J Pharmacol Exp Ther
; 352(2): 327-37, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25502803
4.
Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility.
Bioorg Med Chem
; 22(23): 6570-6585, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25456383
5.
Small molecule therapeutics for neuroinflammation-mediated neurodegenerative disorders.
RSC Med Chem
; 12(6): 871-886, 2021 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34223157
6.
Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo.
Front Mol Neurosci
; 13: 568641, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33192294
7.
PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?
Pain
; 161(7): 1670-1681, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32142016
8.
The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
J Pharmacol Exp Ther
; 328(3): 900-11, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19098165
9.
Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease.
Neurosci Lett
; 705: 7-13, 2019 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30995519
10.
Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.
Sci Transl Med
; 9(412)2017 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29046435
11.
Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases?
F1000Res
; 5: 137, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26998235
12.
Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.
Neuroscience
; 328: 165-83, 2016 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27155150
13.
Radiosynthesis and initial characterization of a PDE10A specific PET tracer [18F]AMG 580 in non-human primates.
Nucl Med Biol
; 42(8): 654-63, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25935386
14.
Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation.
PLoS One
; 9(9): e107151, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25203266
15.
Comparison of phosphodiesterase 10A, dopamine receptors D1 and D2 and dopamine transporter ligand binding in the striatum of the R6/2 and BACHD mouse models of Huntington's disease.
J Huntingtons Dis
; 3(4): 333-41, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25575954
16.
Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).
ACS Med Chem Lett
; 5(6): 700-5, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24944747
17.
Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats.
Pharmacol Biochem Behav
; 105: 41-50, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23380522
18.
Regional, kinetic [(18)F]FDG PET imaging of a unilateral Parkinsonian animal model.
Am J Nucl Med Mol Imaging
; 3(2): 129-41, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23526185
19.
Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice.
Neuropharmacology
; 73: 147-59, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23721744
20.
Characterization of [³H]Lu AE60157 ([³H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine6 (5-HT6) receptors in vivo.
Eur J Pharmacol
; 676(1-3): 6-11, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22155399